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Cannabidiol as a potential treatment for psychosis

2015-12-14
  • 1Tergooi Hospital, Department of Psychiatry, Blaricum, The Netherlands.
  • 2Brain Center Rudolf Magnus, University Medical Centre Utrecht, Department of Psychiatry, The Netherlands.
  • 3Department of Psychosis Studies, Institute of Psychiatry, King’s College London, UK.
  • 4Brain Center Rudolf Magnus, University Medical Centre Utrecht, Department of Psychiatry, The Netherlands. Electronic address: m.p.m.boks@umcutrecht.nl.

Although cannabis use is associated with an increased risk of developing psychosis, the cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review concisely describes the role of the endocannabinoid system in the development of psychosis and provides an overview of currently available animal, human experimental, imaging, epidemiological and clinical studies that investigated the antipsychotic properties of CBD. In this targeted literature review we performed a search for English articles using Medline and EMBASE. Studies were selected if they described experiments with psychosis models, psychotic symptoms or psychotic disorders as outcome measure and involved the use of CBD as intervention. Evidence from several research domains suggests that CBD shows potential for antipsychotic treatment.

 

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